世界*實(shí)驗(yàn)材料供應(yīng)商 Dianova 正式授權(quán)上海起發(fā)為其中國(guó)代理， Dianova 在一直是行業(yè)的*,一直為廣大科研客戶(hù)提供zui為的產(chǎn)品和服務(wù),上海起發(fā)一直秉承為中國(guó)科研客戶(hù)帶來(lái)的產(chǎn)品，的服務(wù)，簽約 Dianova 就是為了給廣大科研客戶(hù)帶來(lái)更加完善的產(chǎn)品和服務(wù),您的滿(mǎn)意將是我們zui大的收獲
Dianova 中國(guó)代理, Dianova 上海代理， Dianova 北京代理，Dianova 廣東代理， Dianova 江蘇代理Dianova 湖北代理,Dianova 天津,Dianova 黑龍江代理,Dianova 內(nèi)蒙古代理,Dianova 吉林代理,Dianova 福建代理, Dianova 江蘇代理, Dianova 浙江代理, Dianova 四川代理,
Dianova公司為德國(guó)的病理免疫組化產(chǎn)品供應(yīng)商，具備的抗體制備工藝及嚴(yán)格的質(zhì)控系統(tǒng)，產(chǎn)品在上享有良好的聲譽(yù)。
克隆號(hào)為H09的IDH1（isocitrate dehydrogenase 1, 異檸檬酸鹽脫氫酶1）鼠單克隆抗體為Dianova公司近期推出的產(chǎn)品之一，此抗體可特異性的檢測(cè)腦組織腫瘤中IDH1基因的R132H點(diǎn)突變。IDH1基因的第132密碼子的雜合突變是II 和III級(jí)神經(jīng)膠質(zhì)瘤（根據(jù)WHO的腫瘤學(xué)分類(lèi)）的頻發(fā)事件。在大約70％的星形膠質(zhì)細(xì)胞瘤和少突神經(jīng)膠質(zhì)細(xì)胞瘤可發(fā)現(xiàn)IDH1基因的R132H點(diǎn)突變。
IDH1基因R132H突變?cè)诓糠帜X腫瘤中的頻發(fā)現(xiàn)象使克隆號(hào)為H09的IDH1抗體可高靈敏性和高特異性的用于此類(lèi)腫瘤的鑒別診斷中：如從原發(fā)性膠質(zhì)母細(xì)胞瘤中區(qū)分出間變性星形細(xì)胞瘤、從毛細(xì)胞型星形細(xì)胞瘤或室管膜（細(xì)胞）瘤中區(qū)分出彌漫性星形細(xì)胞瘤（WHO分類(lèi)II級(jí)），也可以用于具有IDH1突變的腫瘤細(xì)胞浸潤(rùn)前沿的與反應(yīng)性神經(jīng)膠質(zhì)增多癥的區(qū)分。因此，由于其高靈敏性和高特異性，此抗體在腦部腫瘤的分類(lèi)分級(jí)中以及在檢測(cè)單一或少量浸潤(rùn)腫瘤細(xì)胞時(shí)是非常有用的。
Art.-Nr. DIA-303
Spezifität CD3 e
Spezies-Reaktivität Maus
Wirtsspezies Ratte
Isotyp IgG1/k
Klon HH3E
Klonalität (Mono-/Polyklonal) monoklonal
Anwendung Immunhistochemie (IHC)
Immunhistochemie (Paraffingewebe)
Gefrierschnitte (IHC-F)
Western Blot
Konjugation unkonjugiert
Verdünnung Histo-/Zytochemie 1:100
Format Lyophilisat
gereinigter Antikörper (aus Kulturüberstand)
Produktlinie / Thema CD-Marker
Immunhistochemie
Zweckbestimmung nur für Forschungszwecke
Suchcode DIA303M
DIA303
Hersler / Marke dianova
Antibody clone HH3E has been validated specifically for the detection of murine CD3 in formalin-fixed paraffin-embedded tissue sections (mouse FFPE). It detects a conserved epitope on the CD3 epsilon chain in a broad variety of species. CD3 is a defining feature of cells belonging to the T cell lineage and can therefore be used as T cell marker.
Cluster of differentiation 3 (CD3) is composed of four distinct polypeptide chains CD3 gamma, CD3 delta, CD3 epsilon and CD3 zeta, that form a multimeric protein complex. The CD3 complex associates non-covalently with the T cell receptor (TCR) and serves as a T cell co-receptor. The CD3 components have long cytoplasmic tails that associate with cytoplasmic signal trans-duction molecules. The T cell antigen receptor (TCR) recognizes foreign antigens and translates such recognition events into in-tracellular signals that elicit a change in the cell from a dormant to an activated state. During T cell maturation the expression of CD3 migrates from the cytoplasm of pro-thymocytes to the cell-membrane of thymocytes. The specific appearance at all stages of T cell development make CD3 an ideal marker for normal T cells and T cell neoplasms (lymphomas, leukemias). Moreover, CD3 is a usefull immunohistochemical marker for T cells in tissue sections.
In a clinical setting in humans, CD3 serves as an important T cell marker for the classification of malignant lymphomas and leu-kemias. It can also be used to detect T cells in coeliac disease, lymphocytic and collagenous colitis. An anti-CD3 epsilon anti-body (Okt3) has been clinically approved for the induction of immunosuppression in organ transplantation. In animal studies anti-CD3 antibodies can induce tolerance to allografts.
Immunohistochemistry of mouse CD3e (TCRE) in formalin-fixed paraffin-embedded tissue sections
The monoclonal antibody clone HH3E specifically stains mouse tissue sections by IHC-FFPE: Lymph nodes (A,B), spleen (C) and kidney (D).
All sections were stained by an indirect alkaline phosphatase method according to standard procedures with antigen retrieval by high-temperature heating in citrate buffer and counterstaining with Haematoxylin.
A
B
C
D
Related References:
相關(guān)產(chǎn)品信息如下：
| Antibodies / Mouse Histology - IHC FFPE | |||
| 貨號(hào) | 品名 | 規(guī) | 格 |
| DIA-303 | Anti-CD3 (Ms, FFPE) from Rat (Clone: HH3E) | 0.5 | ml |
| DIA-303-M | Anti-CD3 (Ms, FFPE) from Rat (Clone: HH3E) | 0.1 | ml |
| DIA-310 | Anti-CD31 (Ms, FFPE) from Rat (Clone: SZ31) | 0.5 | ml |
| DIA-310-M | Anti-CD31 (Ms, FFPE) from Rat (Clone: SZ31) | 0.1 | ml |
| DIA-404 | Anti-CD4 (Ms, FFPE) from Rat (Clone GHH8) | 0.2 | ml |
| DIA-404-M | Anti-CD4 (Ms, FFPE) from Rat (Clone GHH8) | 0.05 | ml |
| DIA-808 | Anti-CD8a (Ms, FFPE) from Rat (Clone GHH8) | 0.2 | ml |
| DIA-808-M | Anti-CD8a (Ms, FFPE) from Rat (Clone GHH8) | 0.05 | ml |
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6：我們還是Santa,Advanced Biotechnologies Inc, Dianova,bangs,BBInternational,crystalchem,dianova,FD Neurotechnologies,Inc. Dako,Inc, GePromegaridege,Dianova Biotechnology GmbH; iduron,Innovative Research of America, Ludger, neuroprobe,Dianova , Polysciences,prospecbi, QA-BIO,quickzyme,FULLERLABS,INC,sterlitech；sysy,TriLink BioTechnologies,Inc；worthington-biochem,zyagen等幾十家國(guó)外公司授權(quán)代理。
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